Scientist II, Immuno-Pharmacology

Location: Worcester
Posted on: June 23, 2025

Job Description:

Company Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on X , Facebook , Instagram , YouTube , LinkedIn and Tik Tok . Job Description We are seeking a Scientist II to join AbbVies Immunology Discovery organization within the Immuno-Pharmacology and Peptide Discovery department. This lab-based role supports both IND-enabling and early-stage discovery programs in Immunology through hands-on in vitro, ex vivo, and in vivo experimentation.In this position, you will independently investigate, develop, and optimize immunological assays and rodent models to evaluate peptide therapeutics and contribute to platform and program-level research efforts.You will activelyimprove existing workflows,adapt methods from literature, and apply scientific rigor in experimental planning and data interpretation. Playing a key role in integrating experimental pharmacokinetic and pharmacodynamic (PK/PD) dataincluding plasma and tissue exposure and receptor occupancy (RO)you will support translational understanding and dose optimization of orally delivered peptide therapeutics. This includes supporting experimental designs that inform quantitative site-of-action models and doseexposureresponse relationships across tissues and immune compartments. Your responsibilities will involve harvesting and processing relevant tissues (e.g., spleen, lymph nodes, GI tissues, skin), executing cellular and molecular assays, and collaborating cross-functionally to inform biodistribution, RO, and translational model refinement.This position is essential ingenerating data to support cross-functional, data-driven dosing decisions and building the PK/PD relationship for peptide therapeutics at AbbVie. Responsibilities: Experimental Design & Execution: Independently design, execute, and interpret immunological and pharmacological experiments to support IND-enabling and discovery-stage projects across peptide therapeutic programs. Biodistribution/RO & Dose Response Data Generation: Collect and analyze plasma and tissue drug exposure and receptor occupancy (RO) data to support dose-exposure-response predictions and inform oral dosing strategies for peptide candidates. In Vivo Immunology: Perform adoptive transfer, rodent dosing (mice and rats), tissue harvesting, and processing for downstream cellular and molecular analysis of immune responses and target engagement in autoimmune models. Immunological Assays: Execute a variety of immunological assays (e.g., flow cytometry, ELISPOT, co-cultures, cytokine profiling, whole blood assays) to characterize immune responses and evaluate the efficacy of peptide therapeutic candidates. Molecular Techniques: Conduct RNA isolation, qPCR/digital PCR, and related methods to assess gene expression, cytokine responses, and biomarker modulation. Tissue-Based Insights: Process lymphoid and barrier tissues (e.g., GI tract, skin, lymph nodes, spleen) for immune profiling and support receptor occupancy and BioD assessments at relevant disease sites. Model-Enabled Experimentation: Contribute experimental data to support BioD- and PK/PD-driven modeling efforts, including immune cell targeting, dose saturation effects, and target engagement across tissues. Translational Strategy Support: Help refine experimental designs to address translational knowledge gaps and provide data to support clinical prediction models and regulatory packages. Technical Mastery: Demonstrate mastery of in vitro, ex vivo, and in vivo immunology techniques, applying these methods to peptide-focused studies to generate robust, reproducible data. Data Analysis (PK/PD): Interpret pharmacokinetic/pharmacodynamic (PK/PD) data including plasma and tissue exposure levels and receptor occupancy to guide program decisions and optimize peptide therapeutic candidates. Cross-Functional Collaboration: Collaborate cross-functionally with multidisciplinary teams (e.g., DMPK, pharmacology, chemistry) to integrate experimental findings into broader program objectives and ensure alignment with overall peptide therapeutic development goals. Qualifications Education & Experience: BS or MS degree, preferably in biology or a related biological science,with typically 7 (BS) years or 5 (MS) years of relevant industry experience. Experimental Skills: Proven ability to independently design, execute, and interpret critical experiments addressing complex scientific questions in immunology, pharmacology, or related disciplines. Technical Proficiency: Demonstrated hands-on expertise in some of these immunological techniques ELISA, MSD, ELISPOT, flow cytometry, whole blood assays, qPCR/ddPCR, RNA extraction and analysis is preferred, and experience with in vivo rodent procedures (dosing, tissue harvesting, adoptive transfer) in rats and/or mice is required. PK/PD & BioD Experience: Familiarity with concepts of pharmacokinetics (plasma and tissue exposure), receptor occupancy, and dose-exposure-response relationships; demonstrated ability to collect, interpret, and communicate data relevant to these areas. Adaptability & Continuous Learning: Demonstrated ability to rapidly learn, master, and implement new experimental techniques and methodologies to advance scientific objectives. Organizational & Time Management: Strong organizational skills, including the ability to multitask effectively and consistently deliver high-quality results within established project timelines. C ommunication Skills: Excellent scientific writing skills for clear documentation of research findings; strong verbal communication skills for effective presentations and cross-functional collaboration. Collaborative Mindset: Proven ability to work collaboratively across teams, integrating experimental insights with cross-functional groups (e.g., DMPK, pharmacology, clinical sciences) to drive informed, data-driven decisions. Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: The compensation range described below is the range of possible base pay compensation that the Company believes ingood faith it will pay for this role at the time of this posting based on the job grade for this position. Individualcompensation paid within this range will depend on many factors including geographic location, and we may ultimatelypay more or less than the posted range. This range may be modified in the future. Salary: $82,500 - $157,500 We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/visioninsurance and 401(k) to eligible employees. This job is eligible to participate in our short-term incentive programs. Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, and determinable.The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefitsthat are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent with applicable law. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html

Keywords: , East Hartford , Scientist II, Immuno-Pharmacology, Executive , Worcester, Connecticut